The pathophysiology of ICP is still not completely understood. If you have medical concerns, please seek medical attention; if you think your problem could be acute, do so immediately. Is it safe to take ursodeoxycholic acid for so long and does it continue to work for so long? Calamine doesn't touch it - just seems to dry out my skin and make it even more itchy. I had oc at 22 wks with my first baby (Stillborn) due to other complications so please try not to be alarmed. I'm going back this morning for monitoring. Kenyon AP, Piercy CN, Girling J, Williamson C, Tribe RM, Shennan AH. I was induced at 37 weeks and had another beautiful girl who does have a condition called craniosynostosis but that was totally unrelated to the OC. The risk of a stillbirth in a normal pregnancy is about 1 in 200. Good luck with the monitoring. The symptoms get better when your baby has been born. They told me it would disappear within minutes of giving birth - which it did! For the itching - Ursodeoxycholic acid pills can help - your doc should be prescribing these anyway. Genetic, hormonal, and environmental factors may contribute to the pathogenesis of intrahepatic cholestasis of pregnancy. I'm 9 weeks pregnant and have been plagued by an awful rash for the past week, which itches like crazy and is driving me mad! I have now started itching and i wondered if anyone else out there has developed oc at such an early stage. Obstetric cholestasis is uncommon. The itching can increase in severity as the pregnancy progresses, and this can interfere with sleep, concentration and mood. I came home but the itching has woken me up tonight and is unbearable, especially on my hands and feet. My girls are 22 months and 4 months old so it all happened fairly recently. AIBU to not want in-laws on our ‘holiday’? Ursodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis. was used to compare pregnancy outcomes of this group with those of the general obstetric population (n = 16,818). Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis (OC), is a liver disorder that can develop during pregnancy. At what point did other mothers start itching and when were you induced? Hi Dannie, how are you and what happened at the hospital yesterday? World J Gastroenterol. The danger time is after 37 weeks - apparently the risk of stillbirth goes up to 20% after this. Heat makes it worse.I've been particularly careful about what I ate yesterday, as some foods seem to make it worse. | In ICP, the bile acids do not flow properly and build up in your body instead. Thanks prufrock, the itching has stopped and the rash has gone so I guess it was an allergic reaction and I don't have OC. To use this feature subscribe to Mumsnet Premium - get first access to new features see fewer ads, and support Mumsnet. Itching usually occurs on the hands and feet but can also affect other parts of the body.Cholestasis of pregnancy can make you extremely uncomfortable. Sorry to ramble on, Im just a little scared now Ive reached the final stages. The pathophysiology of ICP is still not completely understood. Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy. HHS Have they done LFT's and bile acid tests? If it turns out you don't have OC and just need to get rid of the itching let me know and I'll send you what I've got left. When I got pregnant the last time, my new consultant was really on the ball and I started the oxy-thigummy acid at 30 weeks which did seem to help with the terrible itching. It affects around 0.7% of pregnancies in the UK 1 and typically presents in the third trimester. My consultant was happy to monitor every 2 days at the end - if everything was OK and the baby was moving about lots they were happy I was safe. Hepat Mon. Studies suggest that women from the Indian subcontinent are at a higher risk of developing obstetric cholestasis, which means all Indian pregnant women should be aware of this complication of pregnancy and take precautions against it. Obstetric Obstetric cholestasis - 2nd pregnancy (40 Posts) Add message | Report. The risk if you have obstetric cholestasis may be a little more than this. The condition triggers intense itching, but without a rash. But, having said all of that, I got a horrific rash and itching (up all night and bleeding I scratched so hard) for the last 2 or 3 months of my first pregnancy that turned out to be PPPP (or called something like that...it had lots of P's). Intrahepatic cholestasis of pregnancy is a pregnancy‐specific liver disorder characterized by maternal pruritus in combination with elevated serum total bile acid levels, abnormal liver function, or both. Let's hope it's neither and just allergy/normal itching. You poor thing Dannie. I saw the doctor this week, who thought it was a reaction to pregnancy hormones (it's my 2nd pregnancy, but I had nothing like this in the last one). When you have experienced something like obstetric cholestasis in the past it really is hard to get over. Thanks! Intrahepatic cholestasis of pregnancy (ICP) is a poorly understood disease of the late second or third trimester of pregnancy, typically associated with rapid resolution following delivery. The signs of obstetric cholestasis usually develop around the end of the second trimester, although the disorder can develop earlier in pregnancy. www, i was plagued with rash/itching during months 3 - 6 of my pregnancy. He also told me that it was almost certain that I would continue to get OC with subsequent pregnancies with the risk of permanent liver damage to me so my dear hubbie had the snip when I was 35 weeks gone. Cholestasis is more common in the last trimester of pregnancy when hormones are at their peak, but it … They did tests yesterday and from reading my notes the levels certainly seem high. OP’s posts: See next | See all Add message | Report | See all. Ive been given guidelines as to what I should do the moment the itching starts. Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder in the late second and early third trimester of pregnancy. 2015 Jun 21;21(23):7134-41. doi: 10.3748/wjg.v21.i23.7134. Obstetric cholestasis is a disorder that affects your liver during pregnancy. 0699 to get more advice - they are doing obstetric cholestasis second pregnancy fetal monitoring they will pick up possible... 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